Steroid diagnostics of 21st century in the light of their new roles and analytical tools

Title:

Steroid diagnostics of 21st century in the light of their new roles and analytical tools

Creator:

Dušková, Michaela, Kolátorová Sosvorová, Lucie, Šimková, Markéta, Šrámková, Monika, Malíková, Mária, Horáčková, Lenka, Vítků, Jana, and Stárka, Luboslav

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bd1df592-710f-4e65-b815-05226c2daaf8
uuid:bd1df592-710f-4e65-b815-05226c2daaf8
issn:0862-8408
doi:10.33549/physiolres.934517

Subject:

estrogeny, estrogens, pre-analytical phase, age differences, lesscommon steroids, LC-MS/MS, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

The determination of steroid hormones and subsequent interpretation of results is accompanied by a range of difficulties. The amount of information that current technology can provide on the circulating concentrations of more than a hundred various steroid compounds can lead to problems with interpretation. The aim of this study is to help provide orientation in this maze of data on steroid hormones. First we focus on specific aspects arising from the pre-analytical phase of steroid determination that need to be considered when planning sampling, whether for diagnostics or research. Then, we provide a brief summary of the characteristics and diagnostic relevance of several steroid hormones and/or their metabolites: pregnenolone, 17α-hydroxypregnenolone, dehydroepiandrosterone, hydroxyderivatives of dehydroepiandrosterone, androstenedione, testosterone, estrone, estradiol, estriol, cortisol, cortisone, which in our institute are determined with validated LC-MS/MS methods. For these steroids, we also provide newly calculated reference values in fertile women according to the phase of their menstrual cycle and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

S193-S203

Source:

Physiological research | 2020 Volume:69 | Number:Supplement 2

Harvested from:

CDK

Metadata only:

false