Participation of coenzyme Q10 in the rejection development of the transplanted heart: a clinical study

Title:

Participation of coenzyme Q10 in the rejection development of the transplanted heart: a clinical study

Creator:

Kucharská, J., Gvozdjáková, A., Mizera, S., Braunová, Z., Schreinerová, Z., Schrameková, E., Pecháň, I., and Fabián, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bc17b0f2-78d9-4ff6-8058-2e3242e404db
uuid:bc17b0f2-78d9-4ff6-8058-2e3242e404db

Subject:

human heart transplantation, rejection, coenzyme Qio, and alpha-tocopherol

Type:

article, model:article, and TEXT

Description:

Coenzyme Qio and alpha-tocopherol concentrations were assessed in 28 endomyocardial biopsies from 22 patients and in 61 blood samples from 31 patients after heart transplantation with histologically confirmed signs of rejection. The values were compared to the group of 14 patients with cardiomyopathies of unclear etiology as candidates for heart transplantation. Blood analyses were also compared with 50 healthy persons. Myocardial and blood coenzyme Qio concentrations were already significantly decreased in the incipient phase of rejection (degree 0-1) and also in rejection phase 1 and 2. In patients without rejection signs myocardial and blood coenzyme Qio values were similar to those of cardiomyopathic patients. No significant differences were found in alpha-tocopherol concentrations in relation to signs of rejection. Increased plasma lipid peroxidation quantified as malondialdehyde production was detected in all groups of transplanted patients. The results contribute to the explanation of some pathobiochemical mechanisms participating in the rejection development of the transplanted heart.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1998 Volume:47 | Number:6

Harvested from:

CDK

Metadata only:

false