Adenosine A1, A2a, A2b, and A3 receptors in hematopoiesis. 1. Expression of receptor mRNA in four mouse hematopoietic precursor cells

Title:

Adenosine A1, A2a, A2b, and A3 receptors in hematopoiesis. 1. Expression of receptor mRNA in four mouse hematopoietic precursor cells

Creator:

Denisa Štreitová, Luděk Šefc, Filipp Geirgievich Savvulidi, Pospíšil, M., Jiřina Holá, and Michal Hofer

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b8dce3ec-1315-45e1-a27f-c32088e4d758
uuid:b8dce3ec-1315-45e1-a27f-c32088e4d758

Subject:

Fyziologie člověka a srovnávací fyziologie, adenosinové receptory, krvetvorba, adenosine receptors, hematopoiesis, mRNA expression, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Four mouse bone marrow or thymus cell populations, namely granulopoietic/monocytopoietic, erythropoietic, B-lymphopoietic, and T-lymphopoietic precursor cells have been assayed by RTPCR technique for the presence and relative amounts of adenosine A1, A2a, A2b, and A3 receptor mRNA. It has been found that (i) all four populations studied express all four adenosine receptor subtypes, (ii) the A1 receptor is the least expressed in all populations studied, (iii) the A3 receptor is markedly expressed in the populations of granulopoietic/monocytopoietic and erythropoietic cells, (iv) the A2a receptor is markedly expressed in the populations of B-lymphopoietic and T-lymphopoietic cells, and v) the A2b receptor does not predominate in any of the precursor cells studied. Our data offer a new possibility for the assessment of the readiness of these cells to respond, by receptor-mediated mechanisms, to adenosine or its analogs present in the tissues as a result of endogenous processes and/or following their administration., D. Štreitová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:1

Harvested from:

CDK

Metadata only:

false