Hepatotoxic effect of D-galastosamine and protective role of lipid emulsion

Title:

Hepatotoxic effect of D-galastosamine and protective role of lipid emulsion

Creator:

Ferenčíková, R., Zuzana Červinková, and Zdeněk Drahota

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b79e8cb7-0518-44eb-8afe-04323521436a
uuid:b79e8cb7-0518-44eb-8afe-04323521436a
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, D-galactosamine hepatotoxicity, liver generation, cytochrome c oxidase, lipid emulsion, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

D-galactosamine is a hepatotoxic agent, which induces diffuse injury of liver tissue followed by the regeneration process. Our data showed a high increase of serum aminotransferases after D-galactosamine administration, which indicates a high extent of liver injury. When lipid emulsion was applied immediately after D-galactosamine, the increase of serum aminotransferases was greatly reduced. In addition, the decrease of the cytochrome c oxidase activity induced by D-galactosamine was not observed after lipid emulsion administration and the increase of total liver oxidative capacity in the regeneration period due to activated mitochondrial biogenesis was accelerated. All these findings indicate a protective effect of lipid emulsion administration against D-galactosamine toxicity., R. Ferenčíková, Z. Červinková, Z. Drahota., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2003 Volume:52 | Number:1

Harvested from:

CDK

Metadata only:

false