In vitro susceptibility studies of Malaysian Plasmodium falciparum isolates and clones against schizontocidal drugs

Title:

In vitro susceptibility studies of Malaysian Plasmodium falciparum isolates and clones against schizontocidal drugs

Creator:

Ang, Hooi Hoon, Chan, Kit Lam, and Mak, Joon Wah

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b76bb72f-b868-44eb-a0f5-db13fb8ab73d
uuid:b76bb72f-b868-44eb-a0f5-db13fb8ab73d
urnnbn:urn:nbn:cz:aba007-000dpl

Subject:

Schizontocidal drugs, heterogenous isolates, homogeneous clones, and Plasmodium falciparum.

Type:

model:internalpart and TEXT

Format:

print

Description:

Five Malaysian isolates of the protozoan Plasmodium falciparum Welch were cultured in vitro following the method of Träger and Jensen (1976, 1977) and subsequently cloned using the limiting dilution method of Rosario (1981). Thirty clones were obtained and were later characterized against schizontocidal drugs, chloroquinc, mefloquine and quinine, using the modified in vitro microtechnique. Results showed that these local isolates were heterogenous and most of the clones exhibited similar pattern of susceptibility as their parent isolate except for ST 168 clone and two ST 195 clones that were sensitive but two ST 165 clones, two ST 168 clones and five ST 195 clones were resistant against quinine, respectively. Results also indicated that they were pure clones compared to their parent isolate because their drug susceptibility studies were significantly different (p < 0.05).

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

196-198 and 22-24

Source:

Folia parasitologica | 1998 Volume:45 | Number:3

Harvested from:

CDK

Metadata only:

false