Buffering agent-induced lactose content increases via growth hormone-mediated activation of gluconeogenesis in lactating goats

Title:

Buffering agent-induced lactose content increases via growth hormone-mediated activation of gluconeogenesis in lactating goats

Creator:

Li, L, He, M. L, Zhang, Y. S, and Liu, Y

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b5fa8d20-8f35-416b-9ace-7de95bf266e7
uuid:b5fa8d20-8f35-416b-9ace-7de95bf266e7
issn:0862-8408

Subject:

fyziologie člověka, human physiology, Buffering agent, High-concentrate diet, Lactose, Hepatic gluconeogenesis, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Dairy goats are often fed a high-concentrate (HC) diet to meet their lactation demands; however, long-term concentrate feeding is unhealthy and leads to milk yield and lactose content decreases. Therefore, we tested whether a buffering agent is able to increase the output of glucose in the liver and influence lactose synthesis. Eight lactating goats were randomly assigned to two groups: one group received a HC diet (Concentrate : Forage = 6:4, HG) and the other group received the same diet with a buffering agent added (0.2 % NaHCO3, 0.1 % MgO, BG) over a 19-week experimental period. The total volatile fatty acids and lipopolysaccharide (LPS) declined in the rumen, which led the rumen pH to become stabile in the BG goats. The milk yield and lactose content increased. The alanine aminotransferase, aspartate transaminase, alkaline phosphatase, pro-inflammatory cytokines, LPS and lactate contents in the plasma significantly decreased, whereas the prolactin and growth hormone levels increased. The hepatic vein glucose content increased. In addition, pyruvate carboxylase (PC), phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6- phosphatase (G6PC) expression in the liver was significantly up-regulated. In the mammary glands, the levels of glucose transporter type 1, 8, 12 as well as of sodium-glucose cotransporter 1 increased. Cumulative buffering agent treatment increased the blood concentrations of glucose via gluconeogenesis and promoted its synthesis in the liver. This treatment may contribute to the increase of the milk yield and lactose synthesis of lactating goats., L. Li, M. L. He, Y. Liu, Y. S. Zhang., and Seznam literatury

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:2

Harvested from:

CDK

Metadata only:

false