Relation of cholesterol metabolism and non-cholesterol sterols to insulin resistance

Title:

Relation of cholesterol metabolism and non-cholesterol sterols to insulin resistance

Creator:

Alena Šmahelová, Radomír Hyšpler, and Haas, T.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b4faede7-d997-49c9-8f06-5bfa83b4e475
uuid:b4faede7-d997-49c9-8f06-5bfa83b4e475
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, cholesterol, fytosteroly, physiology, phytosterols, non-cholesterol sterols, metabolic syndrom, cholesterol absorption, cholesterol synthesis, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Using non-cholesterol sterols investigation several authors postulated a hypothesis that in the metabolic syndrome cholesterol endogenous synthesis is increased and its absorption decreased. Our study is the first attempt to evaluate the direct relation of cholesterol metabolism to the principal pathogenetic phenomenon of the metabolic syndrome – namely to insulin resistance. We have measured insulin sensitivity by two methods – Quicki (Quantitative Sensitivity Check Index) and intravenous insulin tolerance test (Kitt) and 3 indirect markers - fasting insulin level, fasting C-peptide level and SHBG (sex hormone binding globulin). The investigation was performed in three groups of subjects with a different prevalence of insulin resistance: 72 non-diabetics with ischemic heart disease, 117 young blood donors and 63 type 2 diabetics on diet therapy only. Analyzing altogether 60 relationships – between four sterols (lathosterol, squalene, sitosterol and campesterol) and five markers of insulin resistance in three groups of subjects – we have found only six significant relations between cholesterol synthesis and absorption and insulin resistance in all groups of patients. Our results indicate that there exists a significant relationship between insulin sensitivity and indices of either increased cholesterol synthesis or decreased cholesterol absorption. Insulin resistance explains only a part of both abnormalities mentioned above., A. Šmahelová, R. Hypšler, T. Haas., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2007 Volume:56 | Number:6

Harvested from:

CDK

Metadata only:

false