Subcellular redistribution of trimeric G-proteins - potential mechanism of desensitization of hormone response: internalization, solubilization, down-regulation

Title:

Subcellular redistribution of trimeric G-proteins - potential mechanism of desensitization of hormone response: internalization, solubilization, down-regulation

Creator:

Drastichová, Z., Lenka Bouřová, Václav Lisý, Lucie Hejnová, Rudajev, V., Jiří Stöhr, Dana Durchánková, Ostašov, P., Jan Teisinger, Tomáš Soukup, Jiří Novotný, and Petr Svoboda

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b3cbe7ef-fca4-498c-afeb-fc9e8267f120
uuid:b3cbe7ef-fca4-498c-afeb-fc9e8267f120
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, neurovědy, mozek, neurosciences, brain, subcellular fractionation, trimeric G-proteins, desensitization, Na, K-ATPase, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Agonist-induced subcellular redistribution of G-protein coupled receptors (GPCR) and of trimeric guanine-nucleotide binding regulatory proteins (G-proteins) represent mechanisms of desensitization of hormone response, which have been studied in our laboratory since 1989. This review brings a short summary of these results and also presents information about related literature data covering at least small part of research carried out in this area. We have also mentioned sodium plus potassium dependent adenosine triphosp hatase (Na, K-ATPase) and 3H-ouabain binding as useful reference standard of plasma membrane purity in the brain., Z. Drastichová, L. Bouřová, V. Lisý, L. Hejnová, V. Rudajev, J. Stöhr, D. Durchánková, P. Ostašov, J. Teisinger, T. Soukup, J. Novotný, P. Svoboda., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:Suppl 3

Harvested from:

CDK

Metadata only:

false