Insights into the physiology of C-peptide

Title:

Insights into the physiology of C-peptide

Creator:

Vejražková, Daniela, Vaňková, Markéta, Lukášová, Petra, Včelák, Josef, and Bendlová, Běla

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b2fe2b41-73eb-4f87-86fa-a8754e4a7f8e
uuid:b2fe2b41-73eb-4f87-86fa-a8754e4a7f8e
issn:0862-8408
doi:10.33549/physiolres.934519

Subject:

inzulin, diabetes mellitus, terapie, insulin, therapy, C-peptide, diabetes complications, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Current knowledge suggests a complex role of C-peptide in human physiology, but its mechanism of action is only partially understood. The effects of C-peptide appear to be variable depending on the target tissue, physiological environment, its combination with other bioactive molecules such as insulin, or depending on its concentration. It is apparent that C-peptide has therapeutic potential for the treatment of vascular and nervous damage caused by type 1 or late type 2 diabetes mellitus. The question remains whether the effect is mediated by the receptor, the existence of which is still uncertain, or whether an alternative non-receptor-mediated mechanism is responsible. The Institute of Endocrinology in Prague has been paying much attention to the issue of C-peptide and its metabolic effect since the 1980s. The RIA methodology of human C-peptide determination was introduced here and transferred to commercial production. By long-term monitoring of C-peptide oGTT-derived indices, the Institute has contributed to elucidating the pathophysiology of glucose tolerance disorders. This review summarizes the current knowledge of C-peptide physiology and highlights the contributions of the Institute of Endocrinology to this issue., Daniela Vejrazkova, Marketa Vankova, Petra Lukasova, Josef Vcelak, Bela Bendlova., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

S237-S243

Source:

Physiological research | 2020 Volume:69 | Number:Supplement 2

Harvested from:

CDK

Metadata only:

false