Erythropoiesis- and thrombopoiesis-characterizing parameters in adenosine A3 receptor knock-out mice

Title:

Erythropoiesis- and thrombopoiesis-characterizing parameters in adenosine A3 receptor knock-out mice

Creator:

Michal Hofer, Milan Pospíšil, Dušek, L., Zuzana Hoferová, Lenka Weiterová, and Komůrková, D.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:b2f9a6f5-49ab-4803-9fa3-ad9c7d94aad7
uuid:b2f9a6f5-49ab-4803-9fa3-ad9c7d94aad7

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, adenosine A3 receptor, mice, erythrocytes, thrombocytes, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Influence of the regulatory system mediated by adenosine A3 receptors on the functioning of erythropoiesis and thrombopoiesis was studied by means of evaluation of the numbers and attributes of peripheral blood erythrocytes and platelets, as well as of erythroid bone marrow progenitor cells in adenosine A3 receptor knock-out (Adora3tm1Jbsn/Adora3tm1Jbsn, A3AR(-/-)) mice and their wild-type C57BL/6 counterparts, both males and females. Minor but statistically significant disturbances in the properties of erythrocytes, namely in the parameters of mean erythrocyte volume and mean erythrocyte hemoglobin were observed in A3AR(-/-) mice. In addition, adenosine A3 receptor knock-out mice were found to exhibit an expressive, statistically significant decrease of their blood platelet count, amounting to 17 % and 21 % in males and females, respectively. This decrease in platelet levels was accompanied by a significant 17 % decline in the plateletcrit in both sexes. The obtained data can help to define therapeutic applications based on the principle of adenosine receptor signaling., M. Hofer, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:3

Harvested from:

CDK

Metadata only:

false