How to interpret elevated plasmatic level of high-sensitive troponin T in newborns and infants?

Title:

How to interpret elevated plasmatic level of high-sensitive troponin T in newborns and infants?

Creator:

Petr Jehlička, Michal Huml, Masopustová, A, Jiří Dort, Matas, M, Alice Mocková, and Daniel Rajdl

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:afc0633a-0c55-4b8d-b6dc-f3376440da94
uuid:afc0633a-0c55-4b8d-b6dc-f3376440da94
issn:0862-8408

Subject:

fyziologie člověka, human physiology, High sensitive troponin T, Infants, Myocardial damage, Newborns, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Research and clinical implications on novel cardiac biomarkers has intensified significantly in the past few years. The highsensitive troponin T (hscTnT) assay plays a dominant role in diagnostic algorithm regarding myocardial injury in adults. Despite generally accepted use of hscTnT there are no data about physiological concentrations and cut-off limits in neonates and infants to date. The aim of this study is to assess hscTnT levels in healthy newborns and infants. Consecutively 454 healthy full termed newborns and 40 healthy infants were enrolled in the study. Samples of cord or venous blood were drawn and tested for hscTnT concentrations with high-sensitive TnT assay (Roche Cobas e602 immunochemical analyzer). The 97.5 percentile of hscTnT concentration was assessed and correlation analysis was performed in neonates. Two hundred and thirteen samples (47 %) were excluded due to blood hemolysis of various degrees in neonates. Finally, the group of 241 healthy newborns was statistically analyzed. The median concentration of hscTnT was 38.2 ng/ml, 97.5 percentile reached 83.0 ng/l (confidential interval 74.1 to 106.9 ng/l). HscTnT concentrations were statistically decreased in hemolytic samples when compared to non-hemolytic samples (34.3 ng/l [26.7 to 42.0 ng/l] and 37.1 ng/l [30.5 to 47.9 ng/l], respectively, p=0.003). Elevated plasma concentrations of hscTnT decreased to adult level within six months. This study has confirmed the higher reference levels of hscTnT in neonates and young infants when compared with adult population. Many extracardiac factors as hemolysis and age may affect the hscTnT level. Based on presented results, a careful clinical interpretation of hscTnT is recommended., P. Jehlička, M. Huml, D. Rajdl, A. Mocková, M. Matas, J. Dort, A. Masopustová., and Seznam literatury

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:2

Harvested from:

CDK

Metadata only:

false