α-actin down regulation and perforin loss in uterine natural killer cells from LPS-treated pregnant mice

Title:

α-actin down regulation and perforin loss in uterine natural killer cells from LPS-treated pregnant mice
Alpha-actin down regulation and perforin loss in uterine natural killer cells from LPS-treated pregnant mice

Creator:

Zavan, B., Amarante-Paffaro A. M. do, and Paffaro, V. A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:aef0536e-2745-4650-a188-a78e5984940e
uuid:aef0536e-2745-4650-a188-a78e5984940e
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, těhotenství, fyziologie, pregnancy, physiology, α-actin, perforin, UNK, lipopolysaccharide, mouse, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

One of the most abundant immunologic cell types in early decidua is the uterine natural killer (UNK) cell that despite the presence of cytoplasmic granules rich in perforin and granzymes does not degranulate in normal pregnancy. UNK cells are important producers of angiogenic factors that permit normal dilation of uterine arteries to provide increased blood flow for the growing feto-placental unit. Gram-negative bacteria lipopolysaccharide (LPS) administration can trigger an imbalance of pro-inflammatory and anti-inflammatory cytokines impairing the normal immune cells activity as well as uterine homeostasis. The present study aimed to evaluate by immunohistochemistry the reactivity of perforin and α-actin on UNK cell from LPStreated pregnant mice. For the first time, we demonstrate that LPS injection in pregnant mice causes α-actin down regulation, concomitantly with perforin loss in UNK cells. This suggests that LPS alters UNK cell migration and activates cytotoxic granule release., B. Zavan, A. M. do Amarante-Paffaro, V. A. Paffaro Jr., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:3

Harvested from:

CDK

Metadata only:

false