Na,K-ATPase from placenta of women with pregnancy-induced hypertension exhibits an increased affinity for cardiac glycosides

Title:

Na,K-ATPase from placenta of women with pregnancy-induced hypertension exhibits an increased affinity for cardiac glycosides

Creator:

Amler, E., Cester, N., Magnanelli, R., Mazzanti, L., Kotyk, A., and Romanini, C.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:abdb0357-a55b-4dd9-a00b-8aad8b0a4cd1
uuid:abdb0357-a55b-4dd9-a00b-8aad8b0a4cd1

Subject:

pregnancy-induced hypertension, cardiac glycosides, human placenta, Na,K-ATPase, and endogenous digitalis-like factor

Type:

article, model:article, and TEXT

Description:

Microsomes were prepared from placentas of normotensive women and of patients suffering from pregnancy- induced hypertension (PIH). Activity of Na,K-ATPase (estimated as ATP hydrolysis) from the hypertensive tissue was lower than from tissue of normotensive women, even if the number of Na,K-ATPase molecules (monitored by anthroyl ouabain binding) was actually greater in the hypertensive tissue. The affinity of Na,K-ATPase for anthroyl ouabain was about four times higher in plasma membranes of hypertensives, indicating some structural change in the Na,K-ATPase or in its vicinity. Assuming the presence of an endogenous digitalis-like factor, the results suggest a simple way of explaining not only the lower Ma,K-ATPase activity in the placental membranes of hypertensives but also the different extent of enzyme inhibition in different tissues of PIH patients.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1994 Volume:43 | Number:1

Harvested from:

CDK

Metadata only:

false