Phosphodiesterases inhibition enhances the effect of glucagon on cardiac automaticity in the isolated right ventricle of the rat

Title:

Phosphodiesterases inhibition enhances the effect of glucagon on cardiac automaticity in the isolated right ventricle of the rat

Creator:

Gonzalez-Muñoz, C. and Hernández, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a88e08c9-140b-4274-b5ae-eceea9badcf7
uuid:a88e08c9-140b-4274-b5ae-eceea9badcf7

Subject:

Fyziologie člověka a srovnávací fyziologie, glukagon, glucagon, cyclic nucleotide phosphodiesterases (PDE), cardiac automaticity, isoproterenol, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

We evaluated the effect of glucagon on cardiac automaticity as well as the possible role of cyclic nucleotide phosphodiesterases (PDE) in regulating this effect. Concentration response curves for glucagon in the absence and in th e presence of the non-selective PDE inhibitor IBMX were performed in the isolated right ventricle of the rat. We found that glucagon produces only a minor increase of ventricular automa ticity (11.0±4.1, n=5) when compared to the full agonist of β-adrenoceptor isoproterenol (182.2±25.3, n=7). However, IBMX enhances the maximal efficacy of glucagon on cardiac automaticity (11.0±4.1, in the absence and 45.3±3.2 in the presence of IBMX, n=5, P<0.05). These results indicate that PDE blunts proarrhythmic effects of glucagon in rat myocardium., C. Gonzalez-Muñoz, J. Hernández., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:1

Harvested from:

CDK

Metadata only:

false