Response of cortisol metabolites in the insulin tolerance test and synacthen tests

Title:

Response of cortisol metabolites in the insulin tolerance test and synacthen tests

Creator:

Kateřina Šimůnková, Michaela Dušková, Mikuláš Kosák, Michal Kršek, Václav Hána, Hill, M., Jandikova, H., Pospíšilová, H., Šrámková, M., Bifulco, E., and Luboslav Stárka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a874e8b7-1883-4734-809f-320e4f227a9e
uuid:a874e8b7-1883-4734-809f-320e4f227a9e
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, kortizol, cortisol, synacthen test, cortisone, insulin tolerance test, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Determination of response of cortisol and its metabolites to different stimuli may be important for adrenal gland disorders. To date, only one metabolite, cortisone, has been followed in stimulation tests of the adrenal gland. We aimed to describe a response of cortisol metabolites to the standard short Synacthen test (HDST), insulin tolerance test (ITT), low dose Synacthen test (LDST) and medium dose Synacthen test (MDST). Sixty healthy subjects were investigated: 30 men and 30 women. Plasma for measurements of cortisol and its metabolites was obtained before and 30th and 60th min after Synacthen and insulin administration. The cut-off 500 nmol/l of cortisol was reached after stimulation in all of tests, the maximal stimulation level was reached in 60th min in all of the tests except for LDST. The response of cortisol and its metabolites at 30th and 60th min strongly correlated in all of the tests except for LDST. Cortisol and its metabolites increased after stimulation; in contrast, cortisone and its metabolites decreased. We showed that the response of the cortisol metabolites during the Synacthen tests and ITT well correlated, and the MDST showed similar response compared to HDST. The decrease in cortisone metabolites may correspond to the regeneration of cortisol from cortisone in response to stimulation test., K. Simunkova, M. Duskova, M. Kosak, M. Krsek, V. Hana, M. Hill, H. Jandikova, H. Pospisilova, M. Sramkova, E. Bifulco, L. Starka., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false