Changes of hippocampal neurons after perinatal exposure to ethanol

Title:

Changes of hippocampal neurons after perinatal exposure to ethanol

Creator:

Milotová, M., Vladimír Riljak, Kateřina Jandová, Jana Bortelová, Dana Marešová, Jaroslav Pokorný, and Miloš Langmeier

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a83fb1ad-e1e6-4b4b-a3ed-8afdc2c0cdc3
uuid:a83fb1ad-e1e6-4b4b-a3ed-8afdc2c0cdc3
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, ethanol, neurodegenerace, apoptóza, physiology, neurodegeneration, apoptosis, hippocampus, dentate gyrus, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The effect of ethanol on the structural development of the central nervous system was studied in offspring of Wistar rats, drinking 20 % ethanol during pregnancy and till the 28th day of their postnatal life. The structural changes in the hippocampus and dentate gyrus were analyzed at the age of 18, 35 and 90 days. A lower width of pyramidal and granular cell layers, cell extinction and fragmentation of numerous nuclei were found in all experimental animals compared to control animals. The extent of neural cell loss was similar in all monitored areas and in all age groups. At the age of 18 and 35 days, the degenerating cells were observed in the CA1 and CA3 area of the hippocampus and in the ventral and dorsal blade of the dentate gyrus. Numerous glial cells replaced the neuronal population of this region. Some degenerating cells with fragmented nuclei were observed at the age of 90 days. Our experiments confirmed the vulnerability of the developing central nervous system by ethanol intake during the perinatal period and revealed a long-lasting degeneration process in the hippocampus and dentate gyrus., M. Milotová, V. Riljak, K. Jandová, J. Bortelová, D. Marešová, K. Pokorný, M. Langmeier., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:2

Harvested from:

CDK

Metadata only:

false