Effects of increased myocardial tissue concentration of myristic, palmitic and palmitoleic acids on the course of cardiac atrophy of the failing heart unloaded by heterotopic transplantation

Title:

Effects of increased myocardial tissue concentration of myristic, palmitic and palmitoleic acids on the course of cardiac atrophy of the failing heart unloaded by heterotopic transplantation

Creator:

Pokorný, M, Mrázová, I, Luděk Červenka, Sadowski, J, Jan Šochman, Vojtěch Melenovský, Hana Maxová, Červenková, L, Doleželová, Š, Zdeňka Vaňourková, Ivan Netuka, Jan Malý, and Jan Pirk

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:a52dbe0c-b54d-41b9-96ec-1c6689e2df57
uuid:a52dbe0c-b54d-41b9-96ec-1c6689e2df57
issn:0862-8408

Subject:

fyziologie člověka, human physiology, Cardiac atrophy, Heterotopic heart transplantation, Mechanical heart unloading, Fatty acids, Heart failure, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

The present experiments were performed to evaluate if increased heart tissue concentration of fatty acids, specifically myristic, palmitic and palmitoleic acids that are believed to promote physiological heart growth, can attenuate the progression of unloading-induced cardiac atrophy in rats with healthy and failing hearts. Heterotopic abdominal heart transplantation (HTx) was used as a model for heart unloading. Cardiac atrophy was assessed from the ratio of the native- to-transplanted heart weight (HW). The degree of cardiac atrophy after HTx was determined on days 7, 14, 21 and 28 after HTx in recipients of either healthy or failing hearts. HTx of healthy hearts resulted in 23±3, 46±3, 48±4 and 46±4 % HW loss at the four time-points. HTx of the failing heart resulted in even greater HW losses, of 46±4, 58±3, 66±2 and 68±4 %, respectively (P<0.05). Activation of “fetal gene cardiac program” (e.g. beta myosin heavy chain gene expression) and “genes reflecting cardiac remodeling” (e.g. atrial natriuretic peptide gene expression) after HTx was greater in failing than in healthy hearts (P<0.05 each time). Exposure to isocaloric high sugar diet caused significant increases in fatty acid concentrations in healthy and in failing hearts. However, these increases were not associated with any change in the course of cardiac atrophy, similarly in healthy and post-HTx failing hearts. We conclude that increasing heart tissue concentrations of the fatty acids allegedly involved in heart growth does not attenuate the unloading-induced cardiac atrophy., M. Pokorný, I. Mrázová, J. Malý, J. Pirk, I. Netuka, Z. Vaňourková, Š. Doleželová, L. Červenková, H. Maxová, V. Melenovský, J. Šochman, J. Sadowski, L. Červenka., and Seznam literatury

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:1

Harvested from:

CDK

Metadata only:

false