Cholesterol lowering and the vessel wall: new insights and future perspectives

Title:

Cholesterol lowering and the vessel wall: new insights and future perspectives

Creator:

Tomáš Štulc and Richard Češka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9b7c661e-4a23-4903-b6c7-3911619cd8f2
uuid:9b7c661e-4a23-4903-b6c7-3911619cd8f2
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, cholesterol, ateroskleróza, endoteliální dysfunkce, akutní koronární syndromy, atherosclerosis, endothelial dysfunction, acute coronary syndromes, cholesterol lowering, plaque stability, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The basis for most acute coronary events is either rupture or fissuring of unstable atherosclerotic plaques with subsequent thrombosis leading to coronary artery occlusion. The development of atherosclerotic plaques takes several decades, but the mechanical features determining its stability and the risk of rupture can change very rapidly depending on a number of internal factors. Unstable plaques have a large lipid core, a thin overlying fibrous cap and an abundance of inflammatory cells. The most important factor determining the plaque stability is the plasma level of atherogenic LDL particles. Increased levels of these particles cause endothelial dysfunction with impaired vasodilatation capacity and prevalence of vasoconstriction, maintain inflammatory infiltration of the plaque, impair the strength of the fibrous cap and facilitate aggregation and coagulation. Effective lowering of plasma cholesterol by pharmacological and non-pharmacological means can revert most of these processes and increase the plaque's mechanical stability within several hours to days. Lipid lowering therapy can therefore decrease the risk of acute coronary events within a very short space of time. Thus a radical decrease in lipid levels, along with modification of other risk factors, may become the cornerstone for treatment of acute coronary syndromes, in addition to being an effective treatment in primary and secondary prevention of coronary heart disease (CHD)., T. Štulc, R. Češka., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:5

Harvested from:

CDK

Metadata only:

false