Antioxidant and pro-oxidant effects of epinephrine and isoprenaline on peroxidation of LDL and lipid liposomes

Title:

Antioxidant and pro-oxidant effects of epinephrine and isoprenaline on peroxidation of LDL and lipid liposomes

Creator:

Ondriaš, K., Staško, A., Gergeľ, D., Hromadová, M., and Mišík, V.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9b758532-c49e-4d74-af75-ab8d8a995cc2
uuid:9b758532-c49e-4d74-af75-ab8d8a995cc2

Subject:

antioxidant, epinephrine, isoprenaline, peroxidation, low density lipoprotein, lipoxidase, and iron

Type:

article, model:article, and TEXT

Description:

Antioxidant or pro-oxidant properties of epinephrine (EPI) and isoprenaline (ISO) were studied in the absence and presence of Fe2+ , Fe3+ and Cu2+ ions. EPI and ISO (>2 /tmol/1) inhibited peroxidation of low density lipoprotein (LDL) induced by 2, 2’-azobis(2-amidino-propane) (AAPH). EPI had a similar inhibitory potency as ISO, but their potency was several times higher than the potency of a-tocopherol (a-TOC). When the LDL peroxidation was induced by 5 /tmol/1 CUSO4, EPI and ISO enhanced LDL peroxidation at low concentrations (10/mol/l) and decreased peroxidation at higher concentrations (30 /tmol/1). The compounds had a similar tendency to inhibit the peroxidation of phosphatidylcholine liposomes. EPI (3-30 //¿mol/1) inhibited lipid peroxidation of phosphatidylcholine liposomes induced by 2 mmol/1 of AAPH, but it was less effective and even increased the peroxidation, when the samples contained 2 mmol/1 AAPH with 50 /¿mol/l FeSC>4 or 2 mmol/1 AAPH with 20/imol/l FeCb. Inhibition of lipid peroxidation by EPI was also observed when studying decreased oxygen consumption, when the peroxidation of linoleic acid was induced by lipoxidase. In conclusion, EPI and ISO reduced lipid peroxidation, but they exhibit pro-oxidant properties in the presence of Fe2+, Fe3+ or Cu2+ ions, depending on the catecholamine and ionic concentration.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1998 Volume:47 | Number:2

Harvested from:

CDK

Metadata only:

false