Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis

Title:

Tempol alleviates chronic intermittent hypoxia-induced pancreatic injury through repressing inflammation and apoptosis

Creator:

Wang, Yeying, Hai, Bing, Ai, Li, Cao, Yu, Li, Ran, Li, Hui, and Li, Yongxia

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9b237db2-bf71-47e3-90e3-6dc2b713cd7c
uuid:9b237db2-bf71-47e3-90e3-6dc2b713cd7c
doi:10.33549/physiolres.934010

Subject:

tempol, intermittent hypoxia, pancreatic injury, inflammation response, and apoptosis

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Obstructive sleep apnea (OSA) has been demonstrated to be implicated in disorder of insulin secretion and diabetes mellitus. In this study, we aimed to evaluate the protective role of tempol, a powerful antioxidant, in chronic intermittent hypoxia (IH)-induced pancreatic injury. The rat model of OSA was established by IH exposure. The pathological changes, increased blood-glucose level, and raised proinsulin/insulin ratio in pancreatic tissues of rats received IH were effectively relieved by tempol delivery. In addition, the enhanced levels of pro-inflammatory cytokines, TNF-α, IL-1β, IL-6, and inflammatory mediators, PGE2, cyclooxygenase-2 (COX-2), NO, and inducible nitric oxide synthase (iNOS) in pancreatic tissue were suppressed by tempol. Moreover, tempol inhibited IH-induced apoptosis in pancreatic tissue as evidenced by upregulated Bcl-2 level, and downregulated Bax and cleaved caspase-3 levels. Finally, the abnormal activation of mitogen-activated protein kinase (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathways induced by IH was restrained by tempol administration. In summary, our study demonstrates that tempol relieves IH-induced pancreatic injury by inhibiting inflammatory response and apoptosis, which provides theoretical basis for tempol as an effective treatment for OSA-induced pancreatic injury.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

445-455

Source:

Physiological research | 2019 Volume:68 | Number:3

Harvested from:

CDK

Metadata only:

false