Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake

Title:

Advanced glycation end-product pentosidine accumulates in various tissues of rats with high fructose intake

Creator:

Mikulíková, K., Adam Eckhardt, Jaroslav Kuneš, Josef Zicha, and Ivan Mikšík

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:985ab1f8-6d66-4727-a65d-79214de20d63
uuid:985ab1f8-6d66-4727-a65d-79214de20d63
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, kardiovaskulární fyziologie, kolagen, cardiovascular physiology, collagen, AGEs (advanced glycation end-products), pentosidine, elastin, glycation, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The slowly metabolized proteins of the extracellular matrix, typically collagen and elastin, accumulate reactive metabolites through uncontrolled non-enzymatic reactions such as glycation or the products arising from the reaction of unsaturated long chain fatty acid metabolites (possessing aldehydic groups). A typical example of these non-enzymatic changes is the formation of advanced glycation end-products (AGEs), resulting from the reaction of carbohydrates with the free amino group of proteins. The accumulation of AGEs and the resulting structural alterations cause altered tissue properties (increased stiffness, reduced elasticity) that contribute to their reduced catabolism and to their aging. Posttranslational nonenzymatic modifications of the proteins of the extracellular matrix (the formation of a typical AGE product - pentosidine) were studied in three types of tissue of three rat strains subjected to a high-fructose diet. Chronic (three-week) hyperglycemia (resulting from fructose loading) caused a significant increase in pentosidine concentration mainly in the aorta and skin of the three rat strains (Lewis, Wistar and hereditary hypertriglyceridemic rats)., K. Mikulíková, A. Eckhardt, J. Kuneš, J. Zicha, I. Mikšík., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:1

Harvested from:

CDK

Metadata only:

false