Differences in Anxiety-Related Behavior Between Apolipoprotein E-Deficient C57BL/6 and Wild Type C57BL/6 Mice

Title:

Differences in Anxiety-Related Behavior Between Apolipoprotein E-Deficient C57BL/6 and Wild Type C57BL/6 Mice

Creator:

McLachlan, C.S. and Yi Xing Soh, C.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:9586be8c-bcd1-4cb5-80d4-125778866dfa
uuid:9586be8c-bcd1-4cb5-80d4-125778866dfa

Subject:

Apolipoprotein E, Anxiety, Elevated plus maze, and Mice

Type:

article, model:article, and TEXT

Description:

The influence of ApoE gene deletion on the anxiety state has not been previously investigated. The elevated plus maze was used in this study to determine differences in anxiety-related behavior between apoE-deficient and wild type C57BL/6 mice. The apoE-deficient mice demonstrated less anxiety on the elevated plus maze by spending more time in the open arms of the elevated plus maze compared to wild type mice (p<0.001). Additionally, female apoE-deficient mice visited the open arm of the maze more often than their apoE-deficient male counterpart (p<0.05). The anxiety state and/or sex are possible variables to be considered when designing physiological and/or behavioral studies involving mice that are apoE-deficient.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2005 Volume:54 | Number:6

Harvested from:

CDK

Metadata only:

false