Endothelin A receptor blockade improves endothelium-dependent relaxation in obese woman

Title:

Endothelin A receptor blockade improves endothelium-dependent relaxation in obese woman

Creator:

Gradin, K. and Persson, B.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:938ae970-214c-4b25-a3ba-ba0146e73d03
uuid:938ae970-214c-4b25-a3ba-ba0146e73d03
issn:0862-8408

Subject:

fyziologie člověka, human physiology, Obesity, Human small arteries, Endothelin, Endothelium, BQ123, Nitric oxide, Women, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Hypertension in obesity is associated with increased insulin resistance, vascular mass and body mass index (BMI). The purpose of the study was to visualize endothelin-1 (ET-1) mediated constriction in arteries isolated from subcutaneous adipose tissue from obese hypertensive women previously operated by gastric bypass. Functional studies were conducted in a microvascular myograph. Expressed as percentage of contraction elicited by 124 mM KCl concentration-response curves for ET-1 were shifted leftward in arteries from obese hypertensive patients compared to healthy normotensive subjects. The vasodilator response to the ET-1 antagonist BQ123 (1 μM) was significantly higher in arteries from obese hypertensive patients (p<0.001). BQ123 induced relaxation was inhibited by NO synthase inhibitor L-NAME (0.1 nM). Preincubation with BQ123 enhanced the relaxation induced by acetylcholine (ACh; 0.1 nM - 0.1 mM) (p<0.001), but not that induced by NO donor sodium nitroprusside (SNP; 0.1 nM - 0.1 mM), in arteries from obese hypertensive patients. The present study show that hypertension yet prevail after gastric bypass surgery and the ETA receptor antagonist BQ123 may be a useful tool in reducing blood pressure in obese hypertensive patients., K. Gradin, B. Persson., and Seznam literatury

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false