A new atherogenic effect of saturated fatty acids

Title:

A new atherogenic effect of saturated fatty acids

Creator:

Rudolf Poledne

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:91744e69-dfc4-46d1-995f-2842dc2edf59
uuid:91744e69-dfc4-46d1-995f-2842dc2edf59

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, diet, fatty acids, lipoproteins, inflammation, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

There is increasing evidence that dietary saturated fatty acids (SAFA) have not only an indirect atherogenic effect due to increasing LDL-cholesterol concentration but also a direct effect by activating the inflammation process. This review summarizes several recent publications in this field. The effect of SAFA on the inflammation process mediated by Toll-like receptor 4/NF-κB pathway has been well documented in various in vitro culture studies of macrophages and adipocytes or in their co-culture. In contrast to these in vitro data, in vivo epidemiological studies or clinical experiments in men are less consistent. Well controlled cross-over studies in volunteers might enlighten the differences between saturated and unsaturated fatty acids dietary intake and proatherogenic inflammation effects., R. Poledne., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:2

Harvested from:

CDK

Metadata only:

false