Exposure to stress alters the effects of dynorphins in the hot plate test

Title:

Exposure to stress alters the effects of dynorphins in the hot plate test

Creator:

Starec, M., Nejedlý, A., Málek, J., Rosina, J., Gojišová, E., and Kršiak, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:90e5e411-8a7f-4da1-bfd3-e05e08d38607
uuid:90e5e411-8a7f-4da1-bfd3-e05e08d38607

Subject:

stress, analgesia, dynorphin, and hot-plate

Type:

article, model:article, and TEXT

Description:

The analgesic effects of intracerebroventricularly (i.c.v.) administered dynorphin A(l-13) and its analog dynorphin A(l-10)amide using the hot plate test were studied in mice. Both dynorphins applied i.c.v. by the freehand method had an analgesic effect but no effect was seen when applied i.c.v. through an implanted cannula. Moreover, freehand i.c.v. injection of saline increased the time of immobility in the forced swimming test and glycaemia levels compared with intact mice. In contrast to the freehand injection, saline administration through an implanted cannula did not influence the immobility of animals in forced swimming test when compared with the intact controls. These results suggest that 1) the freehand method is very stressful procedure of administration which could influence the effects of dynorphins in the hot plate test and 2) dynorphins exert an analgesic effect in the hot plate test only when combined with a stressor (freehand i.c.v. injection).

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1997 Volume:46 | Number:6

Harvested from:

CDK

Metadata only:

false