Hemodynamic Parameters in a Surgical Devascularization Model of Fulminant Hepatic Failure in the Minipig

Title:

Hemodynamic Parameters in a Surgical Devascularization Model of Fulminant Hepatic Failure in the Minipig

Creator:

Kieslichová, E., Ryska, M., Pantoflíček, T., Ryska, O., Zazula, R., and Skibová, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8e418bac-bed0-4e58-95c4-74154224077b
uuid:8e418bac-bed0-4e58-95c4-74154224077b

Subject:

Fulminant/acute hepatic failure, Devascularization surgical pig model, and Hemodynamic parameters

Type:

article, model:article, and TEXT

Description:

Animal models of fulminant hepatic failure (FHF) are important for studying the pathophysiology of this process and for evaluation of the efficacy of artificial and bioartificial liver support systems. In experiments, hemodynamic parameters were monitored in a group of minipigs with FHF induced by surgical devascularization, and compared with those in a control group. During the experiment, animals were analgosedated and were on mechanical lung ventilation. Crystalloid and colloidal solutions were administered and norepinephrine in continuous infusion was applied if mean arterial pressure (MAP) decreased below 60 mm Hg despite adequate intravascular volumes. An increase in heart rate, and decreases in MAP and systemic vascular resistance, compared with the baseline, occurred in the FHF group from 6 h after surgery. A comparison of FHF and control groups revealed no significant differences in systemic vascular resistance and MAP until after 12 h after surgery (systemic vascular resistance index: 953 FHF vs. 1658 controls; p<0.05; MAP: 58.1 FHF vs. 76 controls; p<0.05). No significant differences in CI were seen between the FHF group and controls. FHF animals survived for about 13 h after surgery, i.e. a period, which we consider long enough to test a support device. The parameters are believed to be quite adequate, as we were able to maintain satisfactory hemodynamic stability in all experimental animals with induced acute hepatic failure.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2005 Volume:54 | Number:5

Harvested from:

CDK

Metadata only:

false