Cough reflex sensitivity and fractional exhaled nitric oxide in children with asthma

Title:

Cough reflex sensitivity and fractional exhaled nitric oxide in children with asthma

Creator:

Kunc, Peter, Fabry, Jaroslav, Zatko, Tomas, Grendar, Marian, Tatar, Milos, and Pecova, Renata

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8e30d3a3-ddc2-49fb-9caf-da8507ae53a0
uuid:8e30d3a3-ddc2-49fb-9caf-da8507ae53a0
doi:10.33549/physiolres.934601

Subject:

cough, cough reflex sensitivity, FeNO, children, and asthma

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Individual studies have suggested the utility of fractional exhaled nitric oxide (FeNO) measurement in detecting cough-variant asthma and eosinophilic bronchitis in patients with chronic cough. The aim of this study was to clarify a correlation of cough reflex sensitivity and fractional exhaled nitric oxide in asthmatic children. 25 children with asthma and 15 controls were submitted to cough reflex sensitivity measurement – capsaicin aerosol in doubling concentrations (from 0.61 to 1250 µmol/l) was inhaled by a single breath method. Concentrations of capsaicin causing two (C2) and five coughs (C5) were reported. Fractional exhaled nitric oxide (FeNO) measurement was included. Asthmatic children (11 boys and 14 girls, mean age 9±1 years) and control group (unconfirmed diagnosis of asthma) (6 boys and 9 girls, mean age 8±1 years) were included into the study. FeNO vs. C2 in asthma (Spearman´s rank correlation: -0.146, p=0.49); FENO vs. C5 in asthma (Spearman´s rank correlation: -0.777, p=0.71). We found that there is no correlation between cough reflex sensitivity and fractional exhaled nitric oxide either in children with asthma or in the control group.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

S455-S461

Source:

Physiological research | 2020 Volume:69 | Number:Supplement 3

Harvested from:

CDK

Metadata only:

false