Preadipocyte factor-1 concentrations in patients with anorexia nervosa: the influence of partial realimentation

Title:

Preadipocyte factor-1 concentrations in patients with anorexia nervosa: the influence of partial realimentation

Creator:

Petra Kaválková, Ivana Dostálová, Denisa Haluzíková, Trachta, P., Hanušová, V, Zdeňka Lacinová, Hana Papežová, Daniela Domluvilová, Vít Zikán, and Martin Haluzík

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:86f1d1e2-8cf3-429c-959c-6e615891f808
uuid:86f1d1e2-8cf3-429c-959c-6e615891f808

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, preadipocyte factor-1, anorexia nervosa, realimentation, adipose tissue, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Preadipocyte factor-1 (Pref-1) is a member of epidermal growthfactor like family of proteins that regulates adipocyte and osteoblast differentiation. Experimental studies suggest that circulating Pref-1 levels may be also involved in the regulation of lipid and glucose metabolism and energy homeostasis. We hypothesized that alterations in Pref-1 levels may contribute to the ethiopathogenesis of anorexia nervosa or its underlying metabolic abnormalities. We measured Pref-1 concentrations and other hormonal, biochemical and anthropometric parameters in eighteen patients with anorexia nervosa and sixteen healthy women and studied the influence of partial realimentation of anorexia nervosa patients on these parameters. The mean duration of realimentation period was 46±2 days. At baseline, anorexia nervosa patients had significantly decreased body mass index, body weight, body fat content, fasting glucose, serum insulin, TSH, free T4, leptin and total protein. Partial realimentation improved these parameters. Baseline serum Pref-1 levels did not significantly differ between anorexia nervosa and control group (0.26±0.02 vs. 0.32±0.05 ng/ml, p=0.295) but partial realimentation significantly increased circulating Pref-1 levels (0.35±0.04 vs. 0.26±0.02 ng/ml, p<0.05). Postrealimentation Pref-1 levels significantly positively correlated with the change of body mass index after realimentation (r=0.49, p<0.05). We conclude that alterations in Pref-1 are not involved in the ethiopathogenesis of anorexia nervosa but its changes after partial realimentation could be involved in the regulation of adipose tissue expansion after realimentation., P. Kaválková ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:2

Harvested from:

CDK

Metadata only:

false