Effect of diabetes mellitus type 1 diagnosis on the corneal cell densities and nerve fibers

Title:

Effect of diabetes mellitus type 1 diagnosis on the corneal cell densities and nerve fibers

Creator:

Česká Burdová, M. , Kulich, M. , Dotřelová, D., and Mahelková, G.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8520c14b-d1f2-49e0-9dfb-fe79cde9b664
uuid:8520c14b-d1f2-49e0-9dfb-fe79cde9b664

Subject:

Corneal nerve fibers, diabetic neuropathy, Corneal confocal microscopy, diabetic retinopathy, and age at diagnosis

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Relation of diabetes mellitus (DM) to the various stages of corneal nerve fiber damage is well accepted. A possible association between changes in the cornea of diabetic patients and diabetic retinopathy (DR), DM duration, and age at the time of DM diagnosis were evaluated. The study included 60 patients with DM type 1 (DM1) and 20 healthy control subjects. The density of basal epithelial cells, keratocytes and endothelial cells, and the status of the subbasal nerve fibers were evaluated using in vivo corneal confocal microscopy. Basal epithelial cell density increased with age (p=0.026), while stromal and endothelial cell density decreased with age (p=0.003, p=0.0005, p<0.0001). After the DM1 diagnosis was established, this association with age weaken. We showed nerve fiber damage in DM1 patients (p˂0.0001). The damage correlated with the degree of DR. DM1 patients with higher age at DM1 diagnosis had a higher nerve fiber density (p=0.0021). These results indicated that age at DM1 diagnosis potentially has an important effect on final nerve fiber and corneal cell density.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:6

Harvested from:

CDK

Metadata only:

false