Autonomic nervous system function in newly diagnosed multiple sclerosis: association with lipid levels and insulin resistance

Title:

Autonomic nervous system function in newly diagnosed multiple sclerosis: association with lipid levels and insulin resistance

Creator:

Hardoňová, Miroslava, Šiarnik, Pavel, Siváková, Monika, Suchá, Bianka, Vlček, Miroslav, Imrich, Richard, Turčáni, Peter, Havranová, Andrea, Rádiková, Žofia, Žitňanová, Ingrid, Dean, Zuzana, Penesová, Adela, and Kollár, Branislav

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:8460e658-f40f-4db5-813f-803ba1d4479e
uuid:8460e658-f40f-4db5-813f-803ba1d4479e
doi:10.33549/physiolres.934695

Subject:

multiple sclerosis, autonomic nervous system, autonomic dysfunction, heart rate variability, and lipoproteins

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Autonomic nervous system (ANS) disorders are common in multiple sclerosis (MS). Previous studies showed differences in insulin resistance (IR) and lipoprotein levels in MS subjects compared to controls. Lipolysis caused by increased sympathetic activity could be one of the possible linking mechanisms leading to dyslipidemia in MS. Our study aimed to evaluate ANS activity in the context of glucose and lipid metabolism in people with MS. We prospectively measured short-term heart rate variability (HRV), fasting lipoprotein concentrations, and calculated IR indices based on plasma glucose and insulin levels during oral glucose tolerance test (oGTT) in 32 patients with MS and 29 healthy controls matched for age, sex and body mass index in our study. There was no significant difference in HRV parameters and lipoprotein levels between MS and controls. A significant positive correlation was found between low/high-frequency power ratio (LF/HF) and triglycerides (r=0.413, p=0.021) in MS subjects but not in controls. A significantly lower whole-body insulin sensitivity index (ISIMat) was found in patients with MS compared to the control group (7.3±3.7 vs. 9.8±5.6, p=0.041). No significant correlations were found between LF/HF and IR parameters. In MS subjects, the positive correlation of LF/HF with triglycerides could reflect the effects of sympathetic activity on lipolysis. Positive correlations of sympathetic activity with increased lipoprotein levels could rather reflect processes associated with immune system activation/inflammation, than processes involved in glucose homeostasis maintenance.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

875-882

Source:

Physiological research | 2021 Volume:70 | Number:6

Harvested from:

CDK

Metadata only:

false