Neuroimmunomodulation of natural killer (NK) cells by ergot alkaloid derivatives

Title:

Neuroimmunomodulation of natural killer (NK) cells by ergot alkaloid derivatives

Creator:

Fišerová, A., Kovářů, H., Hajduová, Z., Mareš, V., Starec, M., Křen, V., Flieger, M., and Pospíšil, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:82ade4fb-d041-43f3-ad7e-b5ab526c7ad2
uuid:82ade4fb-d041-43f3-ad7e-b5ab526c7ad2

Subject:

natural killer cells, ergot alkaloids, and neuroimmunomodulation

Type:

article, model:article, and TEXT

Description:

Ergot alkaloids (EAs), products of Claviceps spp., are widely used in various fields of clinical medicine (neurology, psychiatry, endocrinology). In the present work we studied the neuroimmunomodulative effect of EAs on activation of NK cells and their signalling pathways. Furthermore, the killing capability of rat NK cells in vitro was examined in the presence of glycosidic derivatives of elymoclavine, agroclavine, and liposome-encapsulated EAs. The engagement of appropriate NK cell membrane receptors by EAs cause an indirect enhancement of adenylyl cyclase system through inhibition of G-protein a 1,2-subunit (up to 50 % of control values). All of the tested EAs enhanced the rat NK cell-mediated cytotoxic activity in vitro, particularly against target cells of astrocyte origin (C-6 glioma). The present results argue for a possible EA immunomodulatory role of cell-mediated immunity in tumour regression processes.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1997 Volume:46 | Number:2

Harvested from:

CDK

Metadata only:

false