11-Keto-testosterone and other androgens of adrenal origin

Title:

11-Keto-testosterone and other androgens of adrenal origin

Creator:

Stárka, Luboslav, Dušková, Michaela, and Vítků, Jana

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:81c64110-7170-4fca-ae2d-ba7e0cbacfcb
uuid:81c64110-7170-4fca-ae2d-ba7e0cbacfcb
issn:0862-8408
doi:10.33549/physiolres.934516

Subject:

vrozená adrenální hyperplazie, rakovina prostaty, congenital adrenal hyperplasia, prostate cancer, 11β-hydroxy-testosterone, 11-keto-testosterone, adrenarche, 14, and 612

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

The adrenal glands produce significant amounts of steroid hormones and their metabolites, with various levels of androgenic activities. Until recently, the androgenic potency of these adrenal-derived compounds were not well known, but some recent studies have shown that the production of 11-oxoand 11β-hydroxy-derived testosterone and dihydrotestosterone evidently have high androgenic activity. This fact has clinical importance, for instance, in various types of congenital adrenal hyperplasia with androgenization or polycystic ovarian syndrome, and laboratory determinations of these substances could help to better evaluate the total androgen pressure in patients with these disorders. Another area of concern is the treatment of prostate cancer with androgen deprivation, which loses effectiveness after a certain time. The concurrent blocking of the secretion of adrenal C19-steroids, whether using corticoids or adrenostatics, could increase the effectiveness of androgen-deprivation therapy., Luboslav Stárka, Michaela Dušková, Jana Vítků., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

S187-S192

Source:

Physiological research | 2020 Volume:69 | Number:Supplement 2

Harvested from:

CDK

Metadata only:

false