Can bioactive compounds of Crocus sativus L. influence the metabolic activity of selected CYP enzymes in the rat?

Title:

Can bioactive compounds of Crocus sativus L. influence the metabolic activity of selected CYP enzymes in the rat?

Creator:

Dovrtělová, G., Nosková, K., Jan Juřica, Turjap, M., and Zendulka, O.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:81a1a373-ca8d-46fc-8243-9b7aaed49235
uuid:81a1a373-ca8d-46fc-8243-9b7aaed49235
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, metabolismus, physiology, metabolism, crocin, safranal, CYP, rat liver microsomes, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Safranal and crocin are biologically active compounds isolated from Crocus sativus L., commonly known as saffron. Clinical trials confirm that saffron has antidepressant effect, thus being a potential valuable alternative in the treatment of depression. The aim of the present study was to determine, whether systemic administration of safranal and crocin can influence the metabolic activity of CYP3A, CYP2C11, CYP2B, and CYP2A in rat liver microsomes (RLM). The experiments were carried out on male Wistar albino rats intragastrically administered with safranal (4, 20, and 100 mg/kg/day) or with intraperitoneal injections of crocin (4, 20, and 100 mg/kg/day). Our results demonstrate the ability of safranal and crocin to increase the total protein content and to change the metabolic activity of several CYP enzymes assessed as CYP specific hydroxylations of testosterone in RLM. Crocin significantly decreased the metabolic activity of all selected CYP enzymes, while safranal significantly increased the metabolic activity of CYP2B, CYP2C11 and CYP3A enzymes. Therefore, both substances could increase the risk of interactions with co-administered substances metabolized by cytochrome P450 enzymes., G. Dovrtělová, K. Nosková, J. Juřica, M. Turjap, O. Zendulka., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:Suppl 4

Harvested from:

CDK

Metadata only:

false