Galanin receptor 1 plays an antinociceptive effect via inhibiting PKA activation in the nucleus accumbens of rats with neuropathic pain

Title:

Galanin receptor 1 plays an antinociceptive effect via inhibiting PKA activation in the nucleus accumbens of rats with neuropathic pain

Creator:

Zhang, Ying, Gao, Yi, Li, Chong-Yang, Dong, Wei, Dong, Yan, Li, Meng-Nan, Liu, Ya-Nan, and Xu, Shi-Lian

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7ed093b3-26d2-4240-a351-c2585be24607
uuid:7ed093b3-26d2-4240-a351-c2585be24607
doi:10.33549/physiolres.933941

Subject:

antinociception, galanin receptor 1, protein kinase A, neuropathic pain, and nucleus accumbens

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Galanin and galanin receptors (GalRs) have been reported to be involved in the transmission and modulation of nociceptive information in the central nervous system (CNS). However, the underlying mechanism of the antinociception of GalRs in neuropathic pain remains unclear. This study investigated the antinociception induced by galanin receptor 1 (GalR1) via protein kinase A (PKA) signaling pathway in the nucleus accumbens (NAc) of rats with neuropathic pain. A mononeuropathy model was replicated by ligation of the left sciatic nerve, following which the expression of phospho-PKA (p-PKA) in the NAc were markedly up-regulated at 14th and 28th day after ligation of sciatic nerve, and p-PKA expression was down-regulated by intra-NAc injection of GalR1 agonist M617, but the GalR1 antagonist M35 did not have an effect. We also found that M35 in the NAc blocked the M617-induced increase in the hind paw withdrawal latencies (HWLs) of rats with mononeuropathy, but M35 alone had no effect on HWLs, and PKA inhibitor H-89 attenuated the M617-induced an increase in the HWLs. These results suggested that GalR1 induced an antinociception via inhibiting PKA activation, implying that GalR agonists may be potential and potent therapeutic options to treat chronic neuropathic pain.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

511-518

Source:

Physiological research | 2019 Volume:68 | Number:3

Harvested from:

CDK

Metadata only:

false