Effect of indomethacin and deendothelisation on vascular responses in the renal artery

Title:

Effect of indomethacin and deendothelisation on vascular responses in the renal artery

Creator:

Viera Kristová, Milan Kriška, Vojtko, R., and Kurtanský, A.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7e48af6c-425b-4a7c-a4dd-67831df7b486
uuid:7e48af6c-425b-4a7c-a4dd-67831df7b486
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, renal artery, vasoconstrictor responses, indomethacin, deendothelisation, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Vasodilator prostaglandins (PGE2, PGI2) play an important role in the regulation of renal blood flow. Hence, inhibition of their production with nonsteroidal anti-inflammatory drugs increases renal vascular resistance and exerts adverse renal effects. It has been reported that besides endothelium-derived prostaglandin products, nitric oxide (NO) may be mainly involved in regulation of renal functions. The aim of our study was to evaluate the effect of cyclooxygenase inhibition with indomethacin and endothelium removal on vascular responses of the renal artery as a model vessel. Isolated segments of rabbit renal arteries were perfused at constant flow. Indomethacin administration (10-5mol.l-1) significantly increased the responses to single doses (0.1, 1, 10 m g) of noradrenaline (NA) as compared with the controls. In indomethacin-pretreated vessels, subsequent deendothelisation by air bubbles enhanced the constrictor responses to NA. In reversed order, when deendothelisation was followed by indomethacin administration, the responses to NA were similar in character. A comparison of renal artery responses to NA in both experimental situations did not reveal any significant differences. It can be supposed that endothelial and non-endothelial factors may be involved in local regulation of renal vascular tone., V. Kristová, M. Kriška, R. Vojtko, A. Kurtanský., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2000 Volume:49 | Number:1

Harvested from:

CDK

Metadata only:

false