L-arginine in combination with sildenafil potentiates the attenuation of hypoxic pulmonary hypertension in rats

Title:

L-arginine in combination with sildenafil potentiates the attenuation of hypoxic pulmonary hypertension in rats

Creator:

Hikmet Al-Hiti, Martin Chovanec, Vojtěch Melenovský, Olga Vajnerová, Alena Baňasová, Josef Kautzner, and Jan Herget

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7c94110e-01cc-43f1-b7a9-94c33a02f572
uuid:7c94110e-01cc-43f1-b7a9-94c33a02f572

Subject:

Fyziologie člověka a srovnávací fyziologie, plicní hypertenze, pulmonary hypertension, chronic hypoxia, l-arginine, sildenafil, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Chronic hypoxia induces an increased production of nitric oxide (NO) in pulmonary prealveolar arterioles. Bioavailability of the NO in the pulmonary vessels correlates with concentration of L-arginine as well as ac tivity of phosphodiesterase-5 enzyme (PDE- 5). We tested a hypothesis whet her a combination of L-arginine and PDE-5 inhibitor sildenafil has an additive effect in reduction of the hypoxic pulmonary hypertension (HPH) in rats. Animals were exposed to chronic normobaric hypoxia for 3 weeks. In the AH group, rats were administered L-arginine during chronic hypoxic exposure. In the SH group, rats were administered sildenafil during chronic hypoxic exposure. In the SAH group, rats were treated by the combination of L-arginine as well as sildenafil during exposure to chronic hypoxia. Mean PAP, structural remodeling of peripheral pu lmonary arterioles (%DL) and RV/LV+S ratio was significantl y decreased in the SAH group compared to hypoxic controls even decreased compared to the AH and the SH groups in first two measured parameters. Plasmatic concentration of cGMP and NOx were significantly lower in the SAH group compared to hypoxic controls. We demonstrate that NO synthase substrate L-arginine and phosphodiesterase-5 inhibitor sildenafil administered in combination are more potent in attenuation of the HPH compared to a treatment by substances given alone., H. Al-Hiti ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:6

Harvested from:

CDK

Metadata only:

false