Altered blood-brain barrier permeability and its effect on the distribution of Evans blue and sodium fluorescein in the rat brain applied by intracarotid injection

Title:

Altered blood-brain barrier permeability and its effect on the distribution of Evans blue and sodium fluorescein in the rat brain applied by intracarotid injection

Creator:

Petr Kozler and Pokorný, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7aa98f49-fc8f-4cd8-a495-622e1e4585d0
uuid:7aa98f49-fc8f-4cd8-a495-622e1e4585d0
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, hematoencefalická bariéra, fluorescenční mikroskopie, blood-brain barrier, fluorescence microscopy, cellular edema, intravital dyes, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The aim was to study the blood-brain permeability according to the distribution in the rat brain of Evans blue (EB) and sodium fluorescein (NaFl) administered by an intracarotid injection. Eighteen animals were divided into six groups according to the state of the blood-brain barrier (BBB) at the moment when the dyes were being applied. In the first two groups, the BBB was intact, in groups 3 and 4 the barrier had been opened osmotically prior to the application of the dyes, and in groups 5 and 6 a cellular edema was induced by hyperhydration before administration of the dyes. The intracellular and extracellular distribution of the dyes was studied by fluorescence microscopy. The histological picture thus represented the morphological correlate of the way BBB permeability had been changed before the application of the dyes., P. Kozler, J. Pokorný., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2003 Volume:52 | Number:5

Harvested from:

CDK

Metadata only:

false