Influence of amiodarone on urinary excretion of 6β-hydroxycortisol in humans

Title:

Influence of amiodarone on urinary excretion of 6β-hydroxycortisol in humans

Creator:

Stanislav Mičuda, Martin Hodač, Luděk Šišpera, Petr Pařízek, Miloslav Pleskot, Zimová, G., Jaroslav Cerman, Martínková, J., and Vladimír Pidrman

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:787e8b8b-63b4-4283-a951-f01c33df7fd9
uuid:787e8b8b-63b4-4283-a951-f01c33df7fd9
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, kortizol, cortisol, amiodarone, 6β-hydroxycortisol, cytochrome CYP3A, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The present study was undertaken to evaluate the use of cortisol 6b-hydroxylation in defining the effect of amiodarone on cytochrome CYP3A activity. To accomplish this goal, the in vivo activity of CYP3A was estimated by measuring the 24-hour urinary excretion of 6b-hydroxycortisol (6b-OHC) and by calculating 24-hour ratio of 6b-hydroxycortisol to urinary free cortisol (6b-OHC/UFC ratio). Nine cardiac patients scheduled for amiodarone treatment were recruited to participate in this study. Urine was collected over a 24-hour period from each subject before the first amiodarone administration and during the third day of oral administration of amiodarone (200 mg four times daily as a loading dose). Three days of amiodarone treatment caused a significant decrease (p<0.05) in both the 6b-OHC/UFC ratio and the 24-hour urinary excretion of 6b-OHC. These results suggest that amiodarone is an inhibitor of CYP3A activity., S. Mičuda, M. Hodač, L. Šišpera, P. Pařízek, M. Pleskot, G. Zimová, J. Cerman, J. Martínková, V. Pinderman., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:2

Harvested from:

CDK

Metadata only:

false