Neonatal capsaicin administration impairs postnatal development of the cardiac chronotropy and inotropy in rats

Title:

Neonatal capsaicin administration impairs postnatal development of the cardiac chronotropy and inotropy in rats

Creator:

Kuncová, J., Jirkovská, A., Švíglerová, J., Marková, M., Meireles, D., and Čedíková, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:77a1de24-a209-4fac-b5e3-93a6a825e4d0
uuid:77a1de24-a209-4fac-b5e3-93a6a825e4d0

Subject:

Capsaicin, Sensory denervation, Cytotoxicity, Postnatal development, and Rat heart

Type:

article, model:article, and TEXT

Description:

The present study evaluated the impact of neonatal administration of capsaicin (neurotoxin from red hot pepper used for sensory denervation) on postnatal development of the heart rate and ventricular contractility. In the rats subjected to capsaicin administration (100mg/kg) on postnatal days 2 and 3 and their vehicle-treated controls at the ages of 10 to 90 days, function of the sympathetic innervation of the developing heart was characterized by evaluation of chronotropic responses to metipranolol and atropine, norepinephrine concentrations in the heart, and norepinephrine release from the heart atria. Sensory denervation was verified by determination of calcitonin gene-related peptide levels in the heart. Direct cytotoxic effects of capsaicin were assessed on cultured neonatal cardiomyocytes. Capsaicin-treated rats displayed higher resting heart rates, lower atropine effect, but no difference in the effect of metipranolol. Norepinephrine tissue levels and release did not differ from controls. Contraction force of the right ventricular papillary muscle was lower till the age of 60 days. Significantly reduced viability of neonatal cardiomyocytes was demonstrated at capsaicin concentration 100 μmol/l. Our study suggests that neonatal capsaicin treatment leads to impaired maturation of the developing cardiomyocytes. This effect cannot be attributed exclusively to sensory denervation of the rat heart since capsaicin acts also directly on the cardiac cells.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2016 Volume:65 | Number:Suppl 5

Harvested from:

CDK

Metadata only:

false