Bilirubin and atherosclerotic diseases

Title:

Bilirubin and atherosclerotic diseases

Creator:

Libor Vítek

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:76c3f840-dddf-4d76-a5e6-1c756755be3c
uuid:76c3f840-dddf-4d76-a5e6-1c756755be3c
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, bilirubin, ateroskleróza, kardiovaskulární nemoci, atherosclerosis, cardiovascular diseases, benign hyperbilirubinemia, Gilbert syndrome, 14, and 612

Type:

article, články, journal articles, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Bilirubin is the final product of heme catabolism in the systemic circulation. For decades, increased serum/plasma bilirubin levels were considered an ominous sign of an underlying liver disease. However, data from recent years convincin gly suggest that mildly elevated bilirubin concentrations are as sociated with protection against various oxidative stress-mediated diseases, atherosclerotic conditions being the most clinically relevant. Although scarce data on beneficial effects of bilirubin had been published also in the past, it took until 1994 when the first clinical study demonstrated an increased risk of coronary heart disease in subjects with low serum bilirubin levels, and bilirubin was found to be a risk factor for atherosclerotic diseases independent of standard risk factors. Consistent with t hese results, we proved in our own studies, that subjects with mild elevation of serum levels of unconjugated bilirubin (benign hyperbilirubinemia, Gilbert syndrome) have much lower prevalence/incidence of cor onary heart as well as peripher al vascular disease. We have also demonstrated that this association is even more general, with serum bilirubin being a biomarker of numerous other diseases, often associated with increased risk of atherosclerosis. In addition, very recent data have demonst rated biological pathways modulated by bilirubin, which are responsible for observed strong clinical associations., L. Vítek., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false