Delayed effects of elevated corticosterone level on volume of hippocampal formation in laboratory rat

Title:

Delayed effects of elevated corticosterone level on volume of hippocampal formation in laboratory rat

Creator:

Petr Zach, Mrzílková, J., Lenka Řezáčová, Aleš Stuchlík, and Karel Valeš

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7696129e-fa3d-4daa-94c0-e643be204d7c
uuid:7696129e-fa3d-4daa-94c0-e643be204d7c
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, corticosterone, hyppocampus, lateralization, volumetry, long evans rat, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

We studied delayed effects of elevated plasma levels of corticosterone (Cort) on volumetry, neuronal quantity, and gross marks of neurodegeneration in the hippocampal formation of Long-Evans rats. Animals were exposed to increased CORT levels for three weeks via implanted subcutaneous pellets. Volumetry, neuronal quantification and gros s marks of degeneration were measured seven weeks after the termination of CORT treatment. We observed significant differences in volumes and especially in laterality of hippocampal subfields between control and CORT- treated animals. We found th at the left hippocampus was substantially larger than the right hippocampus in the corticosterone-treated group, but not in the control group. In the control group, on the other hand, right hippocampal volume was markedly higher than all other measured volumes (hippocampal left control, hippocampal left CORT-treated and hippocampal right CORT-treated). Left hippocampal volume did not differ between the groups., P. Zach, J. Mrzílková, L. Řezáčová, A. Stuchlík, K. Valeš., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:6

Harvested from:

CDK

Metadata only:

false