LVV-Hemorphin-7 Lowers Blood Pressure in Spontaneously Hypertensive Rats: Radiotelemetry Study

Title:

LVV-Hemorphin-7 Lowers Blood Pressure in Spontaneously Hypertensive Rats: Radiotelemetry Study

Creator:

Čejka, J., Železná, B., Velek, j., Zicha, J., and Kuneš, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:7658cf64-d65b-4b3b-b3c4-4e2bd17c7a91
uuid:7658cf64-d65b-4b3b-b3c4-4e2bd17c7a91

Subject:

Hemorphin, Blood pressure, Heart rate, Hypertension, and Rat

Type:

article, model:article, and TEXT

Description:

Cardiovascular effects of LVV-hemorphin-7, a member of the family of fragments from β-chain of human or bovine hemoglobin, were studied in conscious spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats by radiotelemetry. Intraperitoneal injection of hemorphin in a dose of 100 g/kg significantly decreased blood pressure in SHR, whereas negligible effect was seen in normotensive WKY rats. Blood pressure changes were accompanied by reduction of heart rate. In conclusion, a direct effect of LVV-hemorphin-7 on blood pressure was demonstrated in SHR. These biologically active peptides could be involved in blood pressure regulation especially in hypertensive rats, but the precise mechanism should be elucidated.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2004 Volume:53 | Number:6

Harvested from:

CDK

Metadata only:

false