Bovine leukemia virus-induced clinical signs and morphological changes of encephalitozoonosis in rabbits

Title:

Bovine leukemia virus-induced clinical signs and morphological changes of encephalitozoonosis in rabbits

Creator:

Levkut, Mikuláš, Lesník, František, Bálent, Pavol, Zajac, Vladimír, Korim, Peter, and Sláviková, Katarina

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:72605a89-997c-4a94-bd78-1c2461c7fcc9
uuid:72605a89-997c-4a94-bd78-1c2461c7fcc9
urnnbn:urn:nbn:cz:aba007-000dnv

Subject:

Microsporidia, Encephalilozoon, rabbits, bovine leukemia virus, pathogenesis, and immunohistochemistry

Type:

model:internalpart and TEXT

Format:

print

Description:

Fourteen three-month-old rabbits spontaneously-infected with the microsporidium Encephalilozoon cuniculi Levaditi, Nicolau et Schoen, 1923 were inoculated intravenously with lymphocytes (Ly) from seropositive bovine leukemia virus infected cattle (Ly/BLV) or with fetal lamb kidney cells infected with bovine fetal leukemia (FLK/BLV). Thirteen rabbits were seropositive to BLV at least for a period of three months. Six rabbits died of pulmonary lesions. Chronic inflammatory lesions of ence-phalitozoonosis were found in six rabbits killed between 454 and 548 days of the observation period. Five animals bore subcutaneous granulomas. Immunohistochemically, E. cuniculi was demonstrated in the inflammatory lesions of rabbits studied. Control animals also spontaneously infected with E. cuniculi did not show clinical signs of encephalitozoonosis. Morphological changes were found incidentally in the form of small glial foci and focal interstitial nephritis in these animals. The combined action of BLV - E. cuniculi on the bodies of rabbits is proposed as a suitable model for the study of encephalitozoonosis in man with human immunodeficiency virus (HIV) infection.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

249-254 and 11-16

Source:

Folia parasitologica | 1997 Volume:44 | Number:4

Harvested from:

CDK

Metadata only:

false