Riboflavin supplementation improves energy metabolism in mice exposed to acute hypoxia

Title:

Riboflavin supplementation improves energy metabolism in mice exposed to acute hypoxia

Creator:

Wang, Y. P., Wei, J. Y., Yang, J. J., Gao, W. N., Wu, J. Q., and Guo, C. J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:70e24726-25fe-4835-acbb-eb8af2a33981
uuid:70e24726-25fe-4835-acbb-eb8af2a33981
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, hypoxie, energetický metabolismus, hypoxia, energy metabolism, riboflavin, 1H NMR analysis, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

This study investigated the effects of riboflavin on energy metabolism in hypoxic mice. Kunming mice were fed diets containing riboflavin at doses of 6, 12, 24 and 48 mg/kg, respectively for 2 weeks before exposure to a simulated altitude of 6000 m for 8 h. Changes of riboflavin status and energy metabolism were assessed biochemically. Simultaneously, a 1H nuclear magnetic resonance (NMR) based metabolomic technique was used to track the changes of plasma metabolic profiling. It was found that the content of hepatic riboflavin was decreased and erythrocyte glutathione activation coefficient was elevated significantly under hypoxic condition. Meanwhile, increased plasma pyruvate, lactate, β-hydroxybutyrate and urea, as well as decreased plasma carnitine were observed. Riboflavin supplementation improved riboflavin status remarkably in hypoxic mice and decreased plasma levels of pyruvate, free fatty acids and β-hydroxybutyrate significantly. Plasma carnitine was increased in response to riboflavin supplementation. Results obtained from 1H NMR analysis were basically in line with the data from biochemical assays and remarkable changes in plasma taurine, choline and some other metabolites were also indicated. It was concluded that riboflavin requirement was increased under acute hypoxic condition and riboflavin supplementation was effective in improving energy metabolism in hypoxic mice., Y. P. Wang, J. Y. Wei, J. J. Yang, W. N. Gao, J. Q. Wu, C. J. Guo., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:3

Harvested from:

CDK

Metadata only:

false