Vagal-immune interactions involved in cholinergic anti-inflammatory pathway

Title:

Vagal-immune interactions involved in cholinergic anti-inflammatory pathway

Creator:

Ivan Žila, Daniela Mokrá, Kopincova, J., Kolomaznik, M., Michal Javorka, and Andrea Čalkovská

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6ff64602-0f15-4cbe-96ee-49591711a36c
uuid:6ff64602-0f15-4cbe-96ee-49591711a36c
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, autonomní nervový systém, cytokiny, autonomic nervous system, cytokines, lipopolysaccharide, endotoxemia, vagus nerve, cholinergic anti-inflammatory pathway, inflammatory reflex, 14, and 612

Type:

article, články, journal articles, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Inflammation and other immune responses are involved in the variety of diseases and disorders. The acute response to endotoxemia includes activation of innate immune mechanisms as well as changes in autonomic nervous activity. The autonomic nervous system and the inflammatory response are intimately linked and sympathetic and vagal nerves are thought to have anti-inflammation functions. The basic functional circuit between vagus nerve a nd inflammatory response was identified and the neuroimmunomodulation loop was called cholinergic anti-inflammatory pathway. Unique function of vagus nerve in the anti-inflammatory reflex arc was found in many experimental and pre-clinical studies. They br ought evidence on the cholinergic signaling interacting with systemic and local inflammation, particularly suppressing immune cells function. Pharmacological/electrical modulation of vagal activity suppressed TNF-α and other proinflammatory cytokines prod uction and had beneficial therapeutic effects. Many questions related to mapping, linking and targeting of vagal-immune interactions have been elucidated and brought understanding of its basic physiology and provided the initial support for development of Tracey's inflammatory reflex. This review summarizes and critically assesses the current knowledge defining cholinergic anti-inflammatory pathway with main focus on studies employing an experimental approach and emphasizes the potential of modulation of va gally-mediated anti-inflammatory pathway in the treatment strategies., I. Zila, D. Mokra, J. Kopincova, M. Kolomaznik, M. Javorka, A. Calkovska., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false