Evaluation of hepatic 11β-hydroxysteroid dehydrogenase activity by cortisone acetate test in young adults with diabetes mellitus type

Title:

Evaluation of hepatic 11β-hydroxysteroid dehydrogenase activity by cortisone acetate test in young adults with diabetes mellitus type

Creator:

Kateřina Šimůnková, Richard Hampl, Hill, M., Lubomír Kříž, Jana Vrbíková, Hana Kvasničková, and Karel Vondra

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6af9491c-3f0a-4bc0-b6f3-219053b3ef91
uuid:6af9491c-3f0a-4bc0-b6f3-219053b3ef91

Subject:

Fyziologie člověka a srovnávací fyziologie, kortizol, diabetes mellitus, cortisol, cortisone, cortisone acetate test, peripheral metabolism of glucocorticoids, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Cortisone acetate test was performed in twelve young adult patients with diabetes mellitus type 1, after dexamethasone administration to suppress endogenous cortisol production. Previous screening revealed that all of the subjects had peak cortisol responses in the range from subnormal to normal, as determined by a low-dose Synacthen test. The aim was to find out whether these patients would exhibit different conversion of cortisone to cortisol by 11β-hydroxysteroid dehydrogenase. Using multifactorial ANOVA the following significant relationships were obtained between cortisol or cortisol/cortisone ratio measured during the test and other para meters examined a) before dexamethasone suppression and b) du ring the test: a) Cortisol at 120 th minute negatively correlated with daily insulin dose and positively with basal aldosterone. Cortisol/cortisone ratio at 60th, 120th, 180th, and 240th minute negatively correlated with basal aldosterone/plasma reni n activity ratio, urinary free cortisol/24 hours and positively with basal dehydroepindrosterone sulphate. b) Cortisol at 120th minute negatively correlated with suppressed basal serum glycemia; cortisol/cortisone ratio during the whole test negatively correlated with supressed basal ACTH. The examination of peripheral metabolism of cortisol using cortisone acetate test in patients with di abetes mellitus type 1 showed adaptive changes of 11β-hydroxysteroid dehydrogenace activity associated with altered cortisol tissue supply., K. Šimůnková ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:2

Harvested from:

CDK

Metadata only:

false