Anthracycline therapy and 24-hour blood-pressure profile in long-term survivors of childhood cancer

Title:

Anthracycline therapy and 24-hour blood-pressure profile in long-term survivors of childhood cancer

Creator:

Zuzana Nováková, Jana Šťastná, Honzíková, K., Hana Hrstková, Nataša Honzíková, Eva Závodná, Bohumil Fišer, and Petr Honzík

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6ad2e592-5c5b-4dec-96a3-4c9fc82dc537
uuid:6ad2e592-5c5b-4dec-96a3-4c9fc82dc537

Subject:

Fyziologie člověka a srovnávací fyziologie, krevní tlak, chronobiologie, blood pressure, chronobiology, anthracyclines, cardiotoxicity, childhood cancer, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

In our previous studies, a decreased blood pressure was reported in children treated by anthracycline (AC). The aim of this study was to assess the long-term effects of AC anticancer therapy in 45 subjects aged 13-22 years by repeated 24-hour Holter monitoring of blood pressure. Sixty four aged-matched subjects served as controls. The differences between mean values of systolic (SBP) and diastolic blood pressure (DBP) in each hour of both groups were evaluated by Mann-Whitney test. Also the parameters of the least-squares fit of the sinusoidal curve in each subject were estimated (M - mesor, midline-estimating, a mean value of sinusoidal curve corresponds to 24-hours mean pressure; A - amplitude, double amplitude corresponds to nightday difference; Acr - acrophase is a time of maximal value of a sinusoidal curve). SBP and DBP was significantly lower only during night hours in anthracycline patients 19-22 years old. Also M was lower in this age subgroup of patients comparing to age matched controls (SBP: 112±6 mm Hg versus 117±7 mm Hg, p<0.05; DBP: 67±3 mm Hg versus 69±6 mm Hg, p<0.05), A was not different, Acr in patients was shifted one hour earlier (SBP: 2.4 p.m. versus 3.6 p.m., p<0.05; DBP: 2.1 p.m. versus 3.3 p.m., p<0.01). This corresponds to the shift of the morning blood-pressure increase seen on 24-hours blood pressure profiles. M correlated with age in controls (SBP: r=0.374, p<0.01; regression coefficient b=1.34 mm Hg/1 year; DBP: r=0.365, p<0.01; b=0.95 mm Hg/1 year), but not in patients (SBP: r=0.182, DBP: r=0.064). A and Acr were age-independent in all subjects. It is concluded that blood pressure in 19-22 years old AC patients is lower during night hours, the age-dependent increase of blood pressure seen in healthy controls between 13 and 22 years of age does not occur in patients. This finding is consistent with the long-lasting impairment of the sympathetic nervous system caused by anthracyclines., Z. Nováková ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false