VO2 kinetics in supra-anaerobic threshold constant tests allow the visualization and quantification of the O2 saving after cytochrome C oxidase inhibition by aerobic training or nitrate administration

Title:

VO2 kinetics in supra-anaerobic threshold constant tests allow the visualization and quantification of the O2 saving after cytochrome C oxidase inhibition by aerobic training or nitrate administration

Creator:

Maione, D., Cicero, A. F. G., Bacchelli, S., Cosentino, E., Degli Esposti, D., Senaldi, R., Strocchi, E., D'Addato, S., and Borghi, C.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:68ed5a33-ca2d-4485-a695-bd3fdc357f66
uuid:68ed5a33-ca2d-4485-a695-bd3fdc357f66

Subject:

Fyziologie člověka a srovnávací fyziologie, cytochromy, dusičnany, cytochromes, nitrates, oxygen consuption, anaerobic threshold, VO2 kinetics, cytochrome c oxidase inhibition, training, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

We tested whether the known cytochrome c oxidase (COX) inhibition by nitric oxide (NO) could be quantified by VO 2 kinetics during constant load supra-Anaero bic Threshold (AT) exercises in healthy trained or untrained subjects following aerobic training or nitrate administration. In cycle er gometer constant load exercises supra-AT, identified in previous incremental tests, VO 2 kinetics describe a double exponential curve, one rapid and one appreciably slower, allowing the area between them to be calculate in O 2 l. After training, with increased NO availability, this area decreases in inverse ratio to treatment efficacy. In fact, in 11 healthy subjects after aerobic tr aining for 6-7 weeks, area was decreased on average by 51 %. In 11 untrained subjects, following the assumption of an NO donor, 20 mg isosorbide 5 mononitrate, area was decrea sed on average by 53 %. In conclusion, supra-AT VO 2 kinetics in constant load exercises permit the quantification of the inhibitory effect NO-dependent on COX after either physical training or nitrate assumption., D. Maione ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:6

Harvested from:

CDK

Metadata only:

false