Effects of vitamin E and prostaglandin E2 on expression of CREB1 and CREB2 proteins by human T lymphocytes

Title:

Effects of vitamin E and prostaglandin E2 on expression of CREB1 and CREB2 proteins by human T lymphocytes

Creator:

Valenti, A., Venza, I., Venza, M., Fimiani, V., and Teti, D.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:68238f13-3d58-4cde-9daf-8af3ba314735
uuid:68238f13-3d58-4cde-9daf-8af3ba314735
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, vitamin E, T lymfocyty, T lymphocytes, PGE2, CREB proteins, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Both prostaglandins (PGs) and vitamin E are known to deeply affect immune responses. It is shown here that they both influence T cell-mediated immunity through reciprocal interference on the expression of cyclic-AMP responsive element binding (CREB) family proteins. CREB1 protein of human T lymphocytes was significantly modulated by a brief treatment of 5 to 10 min with PGE2. On the contrary, vitamin E appeared to be ineffective on the CREB1 behavior, while it abolished the PGE2-induced modulation of this protein. The CREB2 protein expression was also affected by PGE2 treatment, but a longer period of incubation (>20 min) was needed to observe these changes. Vitamin E showed a strong enhancing effect on CREB2 that was partially reversed by the subsequent treatment with PGE2. Our results support the idea that there is reciprocal interference between PGE2 and vitamin E on PGE2-induced signals in T lymphocytes. These data are in agreement with the reports concerning different cell systems and experimental conditions., A. Valenti, I. Venza, M. Venza, V. Fimiani, D. Teti., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2000 Volume:49 | Number:3

Harvested from:

CDK

Metadata only:

false