Effect of salivary gland extract from Ixodes ricinus ticks on the proliferation of Borrelia burgdorferi sensu stricto in vivo

Title:

Effect of salivary gland extract from Ixodes ricinus ticks on the proliferation of Borrelia burgdorferi sensu stricto in vivo

Creator:

Macháčková, Martina, Oborník, Miroslav, and Kopecký, Jan

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:6441a529-a13b-4e90-9d1d-e269f977cd67
uuid:6441a529-a13b-4e90-9d1d-e269f977cd67
doi:10.14411/fp.2006.020

Subject:

Borrelia burgdorferi, Ixodes ricinus, saliva-activated transmission, salivary gland extract, and real-time PCR

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Saliva-activated transmission (SAT) of Borrelia burgdorferi sensu stricto was demonstrated using real-time PCR and salivary gland extract (SGE) from partially fed Ixodes ricinus ticks. C3H/HeN mice were injected intradermally with 1.5 × 103 spirochetes mixed with 40 µg of SGE per mouse. The control group was inoculated with the same dose of spirochetes without SGE. The accelerating effect of SGE on spirochete proliferation was demonstrated on day 1 post infection, when a 4.2-fold increase in spirochetes was found in the skin and a 10-fold increase in the blood, compared with control mice. The data represent the first direct evidence of a SAT effect of I. ricinus SGE on infection with the Lyme disease agent B. burgdorferi.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

153-158

Source:

Folia parasitologica | 2006 Volume:53 | Number:2

Harvested from:

CDK

Metadata only:

false